Abstinent adult daily smokers show reduced anticipatory but elevated saccade-related brain responses during a rewarded antisaccade task
Identifieur interne : 004149 ( Main/Exploration ); précédent : 004148; suivant : 004150Abstinent adult daily smokers show reduced anticipatory but elevated saccade-related brain responses during a rewarded antisaccade task
Auteurs : Charles F. Geier [États-Unis] ; Maggie M. Sweitzer [États-Unis] ; Rachel Denlinger [États-Unis] ; Gina Sparacino [États-Unis] ; Eric C. Donny [États-Unis]Source :
- Psychiatry research [ 0165-1781 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse et exécution des tâches, Cortex préfrontal (physiopathologie), Encéphale (physiopathologie), Femelle, Gyrus du cingulum (physiopathologie), Humains, Imagerie par résonance magnétique, Lobe frontal (physiopathologie), Lobe pariétal (physiopathologie), Modèles linéaires, Mâle, Prise de décision, Récompense, Saccades, Sevrage tabagique, Striatum ventral (physiopathologie), Sujet âgé, Tabagisme (physiopathologie).
- MESH :
- physiopathologie : Cortex préfrontal, Encéphale, Gyrus du cingulum, Lobe frontal, Lobe pariétal, Striatum ventral, Tabagisme.
- Adulte, Adulte d'âge moyen, Analyse et exécution des tâches, Femelle, Humains, Imagerie par résonance magnétique, Modèles linéaires, Mâle, Prise de décision, Récompense, Saccades, Sevrage tabagique, Sujet âgé.
English descriptors
- KwdEn :
- Adult, Aged, Brain (physiopathology), Decision Making, Female, Frontal Lobe (physiopathology), Gyrus Cinguli (physiopathology), Humans, Linear Models, Magnetic Resonance Imaging, Male, Middle Aged, Parietal Lobe (physiopathology), Prefrontal Cortex (physiopathology), Reward, Saccades, Smoking (physiopathology), Smoking Cessation, Task Performance and Analysis, Ventral Striatum (physiopathology).
- MESH :
Abstract
Chronic smoking may result in reduced sensitivity to non-drug rewards (e.g., money), a phenomenon particularly salient during abstinence. During a quit attempt, this effect may contribute to biased decision-making (smoking > alternative reinforcers) and relapse. Although relevant for quitting, characterization of reduced reward function in abstinent smokers remains limited. Moreover, how attenuated reward function affects other brain systems supporting decision-making has not been established. Here, we use a rewarded antisaccade (rAS) task to characterize non-drug reward processing and its influence on inhibitory control, key elements underlying decision-making, in abstinent smokers vs. non-smokers. Abstinent (12-hours) adult daily smokers (
Url:
DOI: 10.1016/j.pscychresns.2014.04.007
PubMed: 24914005
PubMed Central: 5428387
Affiliations:
- États-Unis
- Pennsylvanie
- Pittsburgh, University Park (Pennsylvanie)
- Université d'État de Pennsylvanie, Université de Pittsburgh
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Le document en format XML
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Geier</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Human Development and Family Studies, The Pennsylvania State University, University Park, PA 16802, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Development and Family Studies, The Pennsylvania State University, University Park, PA 16802</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">University Park (Pennsylvanie)</settlement></placeName><orgName type="university">Université d'État de Pennsylvanie</orgName></affiliation></author><author><name sortKey="Sweitzer, Maggie M" sort="Sweitzer, Maggie M" uniqKey="Sweitzer M" first="Maggie M." last="Sweitzer">Maggie M. Sweitzer</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Denlinger, Rachel" sort="Denlinger, Rachel" uniqKey="Denlinger R" first="Rachel" last="Denlinger">Rachel Denlinger</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Sparacino, Gina" sort="Sparacino, Gina" uniqKey="Sparacino G" first="Gina" last="Sparacino">Gina Sparacino</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Donny, Eric C" sort="Donny, Eric C" uniqKey="Donny E" first="Eric C." last="Donny">Eric C. Donny</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></analytic><series><title level="j">Psychiatry research</title><idno type="ISSN">0165-1781</idno><idno type="eISSN">1872-7123</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain (physiopathology)</term><term>Decision Making</term><term>Female</term><term>Frontal Lobe (physiopathology)</term><term>Gyrus Cinguli (physiopathology)</term><term>Humans</term><term>Linear Models</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Parietal Lobe (physiopathology)</term><term>Prefrontal Cortex (physiopathology)</term><term>Reward</term><term>Saccades</term><term>Smoking (physiopathology)</term><term>Smoking Cessation</term><term>Task Performance and Analysis</term><term>Ventral Striatum (physiopathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse et exécution des tâches</term><term>Cortex préfrontal (physiopathologie)</term><term>Encéphale (physiopathologie)</term><term>Femelle</term><term>Gyrus du cingulum (physiopathologie)</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Lobe frontal (physiopathologie)</term><term>Lobe pariétal (physiopathologie)</term><term>Modèles linéaires</term><term>Mâle</term><term>Prise de décision</term><term>Récompense</term><term>Saccades</term><term>Sevrage tabagique</term><term>Striatum ventral (physiopathologie)</term><term>Sujet âgé</term><term>Tabagisme (physiopathologie)</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Cortex préfrontal</term><term>Encéphale</term><term>Gyrus du cingulum</term><term>Lobe frontal</term><term>Lobe pariétal</term><term>Striatum ventral</term><term>Tabagisme</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Frontal Lobe</term><term>Gyrus Cinguli</term><term>Parietal Lobe</term><term>Prefrontal Cortex</term><term>Smoking</term><term>Ventral Striatum</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Decision Making</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Reward</term><term>Saccades</term><term>Smoking Cessation</term><term>Task Performance and Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse et exécution des tâches</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Modèles linéaires</term><term>Mâle</term><term>Prise de décision</term><term>Récompense</term><term>Saccades</term><term>Sevrage tabagique</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Chronic smoking may result in reduced sensitivity to non-drug rewards (e.g., money), a phenomenon particularly salient during abstinence. During a quit attempt, this effect may contribute to biased decision-making (smoking > alternative reinforcers) and relapse. Although relevant for quitting, characterization of reduced reward function in abstinent smokers remains limited. Moreover, how attenuated reward function affects other brain systems supporting decision-making has not been established. Here, we use a rewarded antisaccade (rAS) task to characterize non-drug reward processing and its influence on inhibitory control, key elements underlying decision-making, in abstinent smokers vs. non-smokers. Abstinent (12-hours) adult daily smokers (<italic>N</italic>=23) and non-smokers (<italic>N</italic>=11) underwent fMRI while performing the rAS. Behavioral performances improved on reward vs. neutral trials. Smokers showed attenuated activation in ventral striatum during the reward cue and in superior precentral sulcus and posterior parietal cortex during response preparation, but greater responses during the saccade response in posterior cingulate and parietal cortices. Smokers' attenuated anticipatory responses suggest reduced motivation from monetary reward, while heightened activation during the saccade response suggests that additional circuitry may be engaged later to enhance inhibitory task performance. Overall, this preliminary study highlights group differences in decision-making components and the utility of the rAS to characterize these effects.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li><li>University Park (Pennsylvanie)</li></settlement><orgName><li>Université d'État de Pennsylvanie</li><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Geier, Charles F" sort="Geier, Charles F" uniqKey="Geier C" first="Charles F." last="Geier">Charles F. Geier</name></region><name sortKey="Denlinger, Rachel" sort="Denlinger, Rachel" uniqKey="Denlinger R" first="Rachel" last="Denlinger">Rachel Denlinger</name><name sortKey="Donny, Eric C" sort="Donny, Eric C" uniqKey="Donny E" first="Eric C." last="Donny">Eric C. Donny</name><name sortKey="Sparacino, Gina" sort="Sparacino, Gina" uniqKey="Sparacino G" first="Gina" last="Sparacino">Gina Sparacino</name><name sortKey="Sweitzer, Maggie M" sort="Sweitzer, Maggie M" uniqKey="Sweitzer M" first="Maggie M." last="Sweitzer">Maggie M. Sweitzer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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